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Niki de Saint Phalle (French: [niki d(ə) sɛ̃ fal]; born Catherine Marie-Agnès Fal de Saint Phalle; 29 October 1930 – 21 May 2002) was a French American sculptor, painter, filmmaker, and author of colorful hand-illustrated books. Widely noted as one of the few female monumental sculptors, Saint Phalle was also known for her social commitment and work.

She had a difficult and traumatic childhood and a much-disrupted education, which she wrote about many decades later. After an early marriage and two children, she began creating art in a naïve, experimental style. She first received worldwide attention for angry, violent assemblages which had been shot by firearms. These evolved into Nanas, light-hearted, whimsical, colorful, large-scale sculptures of animals, monsters, and female figures. Her most comprehensive work was the Tarot Garden, a large sculpture garden containing numerous works ranging up to house-sized creations.

Saint Phalle's idiosyncratic style has been called "outsider art"; she had no formal training in art, but associated freely with many other contemporary artists, writers, and composers. Her books and abundant correspondence were written and brightly colored in a childish style, but throughout her lifetime she addressed many controversial and important global problems in the bold way children often use to question and call out unacceptable neglect.

Throughout her creative career, she collaborated with other well-known artists such as Jasper Johns, Robert Rauschenberg, Larry Rivers, composer John Cage, and architect Mario Botta, as well as dozens of lesser-known artists and craftspersons. For several decades, she worked especially closely with Swiss kinetic artist Jean Tinguely, who also became her second husband. In her later years, she suffered from multiple chronic health problems attributed to repeated exposure to airborne glass fibers and petrochemical fumes from the experimental materials she had used in her pioneering artworks, but she continued to create prolifically until the end of her life.

A critic has observed that Saint Phalle's "insistence on exuberance, emotion and sensuality, her pursuit of the figurative and her bold use of color have not endeared her to everyone in a minimalist age". She was well known in Europe, but her work was little-seen in the US, until her final years in San Diego. Another critic said: "The French-born, American-raised artist is one of the most significant female and feminist artists of the 20th century, and one of the few to receive recognition in the male-dominated art world during her lifetime".